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An algorithm to distinguish between distant metastases and metachronous lung primary in patients with HPV-related oropharyngeal cancer
Distinguishing between distant metastases of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) and metachronous primary lung squamous cell carcinoma (SCC) is important as it has implications for treatment, prognosis counselling, and registry data. Although p16 immunohistochemistry (p16 IHC) is widely accepted...
A drug to prevent hearing loss caused by ototoxic therapeutics
This editorial briefly highlights the progress made in discovering a compound named ORC-13661, which shows the potential to alter the response of hair cells to ototoxic medication. In the late 1980s, inner hair cells that were lost secondary to noise...
Occupational hazards affecting otolaryngologists
This is a questionnaire survey which received responses from 323 clinicians practising otolaryngology. The grades ranged from consultants to junior doctors. It was noted that nearly half of these respondents suffered from some form of musculoskeletal pain and it highlights...
Management of the ear in cleft lip and palate
The management of patients with cleft lip and palate includes a focus on effective speech and language function. Poor eustachian tube function and middle ear dysfunction mean over 90% of children suffer from otitis media with effusion. This article provides...
Can obstructive snoring affect the snorer’s ears as well?
Patients with obstructive sleep apnoea (OSA) often show severe nasal obstruction, chronic sinusitis and/or a deficit of nasal mucociliary clearance with nasopharyngeal stagnation of secretions possibly predisposing to eustachian tube dysfunction (ETD). This clinical prospective study investigates ETD, nasal resistance...
Bile acids and pharyngeal malignancy
Laryngopharyngeal reflux is a commonly described condition. There is strong evidence linking gastro-oesophageal reflux with oesophageal carcinomas. Gastric refluxate consists of gastric acid, pepsin and bile acids. The roles of pepsin and acidic conditions in the development of laryngopharyngeal carcinoma...
What should be considered a ‘close’ margin in oral cavity squamous cell carcinoma?
Achieving clear margins during surgical resection in oral cavity squamous cell carcinoma (OCSCC) is thought to reduce local recurrence (LR) and improve prognosis; however, what constitutes a clear, close, or involved margin is inconsistent in the literature and in practice....
Identifying clinically useful salivary substitutes
This in vitro study analysed the efficacy of salivary substitutes used in the treatment of xerostomia following head neck irradiation. The researchers applied the products under evaluation onto a synthetic surface and onto cellular gingival models. The products were then...
Radiosurgery for large vestibular schwannomas
The authors conducted a retrospective study of patients with large Koos grade 4 vestibular schwannomas undergoing gamma knife radiosurgery. A total of 68 patients with tumour size greater than 4 cm3 with baseline serviceable 60% hearing who received 12 Gray...
Auditory neuropathy spectrum disorder
This is a concise summary of auditory neuropathy and current knowledge of the disorder through review of a recently published article. The terminology of this hearing disorder implies the site of the lesion is neural; however the characteristic electrophysical signature...
Team based learning in speech language pathology graduate courses
According to the author of this article, the role of a speech language pathologist involves clinical problem solving in both diagnostic and treatment processes. Problem solving involves cooperative collaboration with clients and their parents. Therefore, in this pilot study, the...
