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Endotypes in chronic rhinosinusitis: clinical relevance
Identifying endotypes enables personalised therapies that target specific pathophysiological processes, potentially resulting in better treatment outcomes for patients. The contemporary model of chronic rhinosinusitis (CRS) pathogenesis revolving around endotype, in combination with an expanding toolbox of diagnostics and therapeutics, enables...
Pituitary tumour associated headaches
This longitudinal cohort study presents data with significant clinical implications for patients with headaches and the clinicians and surgeons who treat them. For the study, patients completed a self-administered survey on headache characteristics on initial presentation and after surgery of...Per-Ingvar Brånemark: father of osseointegration
The application of osseointegration has been central to the development of both bone-anchored hearing aids and dental implants. But how did it all come about? Per-Ingvar Brånemark (1929–2014). Image Johan Wingborg. Many hearing-impaired patients owe a great debt of gratitude...
The hippo and the nose
Chronic rhinosinusitis with nasal polyps (CRSwNP) leads to histological changes including thickening of the basilar membrane and epithelial proliferation. Molecular mechanisms underlying these changes are still not fully clear. A signalling pathway called the hippo with Yes‐associated protein (YAP) as...
Awareness of alternative techniques in cochlear implantation
The use of alternative techniques for cochlear implantation is indicated in unusual cases where the standard procedure would not be suitable. The authors of this study highlight the various reasons as to why an alternative technique might be sought, and...
Patient-reported outcome measures: what do the people say?
Patient-reported outcome measures (PROMs) assess and quantify health outcomes from the patient’s perspective. Defining these questionnaires as outcomes indicates that they are psychometrically sensitive to change. This article describes three PROMS: namely the Patient Reported Outcome Measurement Information System (PROMIS),...
An algorithm to distinguish between distant metastases and metachronous lung primary in patients with HPV-related oropharyngeal cancer
Distinguishing between distant metastases of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) and metachronous primary lung squamous cell carcinoma (SCC) is important as it has implications for treatment, prognosis counselling, and registry data. Although p16 immunohistochemistry (p16 IHC) is widely accepted...
Which factors affect music involvement in implanted children’s everyday life?
During the last few years, cochlear implantation research has included music. Processing strategies and rehabilitation teams are now interested in music appreciation by implantees, as speech perception and production are no longer the only issues or targets. The present study...Endoscopic CSF leak repair using nasoseptal flap
Many of us during training or in established practice will have encountered the complication of anterior skull base CSF leak. This can be a challenging problem to deal with and in this article the authors describe their favoured approach. Cerebrospinal...Working with people with hearing loss and dementia
A member of the SENSE-Cog team in the UK, Dr Littlejohn provides an overview of multidisciplinary recommendations for diagnosis, management and care of older adults with hearing loss, vision loss and dementia. She underscores how consideration of hearing status when...
