Spinocerebellar and Friedreich ataxias (SCA and FA) by their nature present in neuro-otology clinics. The diagnosis is ultimately genetic but the authors investigated the characteristics of the VOR using the video head impulse test (vHIT) in order to distinguish between...
Chronic rhinosinusitis with nasal polyps (CRSwNP) leads to histological changes including thickening of the basilar membrane and epithelial proliferation. Molecular mechanisms underlying these changes are still not fully clear. A signalling pathway called the hippo with Yes‐associated protein (YAP) as...
In this article, Alhabib et al consider the changes to electrode impedance with early device activation (day one) compared to conventional activation (day 30). Activation at day 30 is a cautious approach, which has been popular for many years. However,...
Hypoparathyroidism is one of the most common complications of thyroid surgery. There is significant controversy in calcium management practices post thyroid surgery. The drop in PTH levels has been used to predict the likelihood of hypocalcaemia after thyroid surgery. But...
Untreated reflux can cause inflammation, scarring, narrowing and precancerous changes in the oesophagus and larynx, and may increase the risk of asthma and sleep apnoea.
Placement of voice prosthesis at the time of trachea-oesophageal puncture is well described using 20-French prostheses. There is debate about the optimal size of the prosthesis with work in the 1980s and 1990s supporting larger prostheses. The rationale was that...
This is the second Thieme book on head and neck cancer by this author that follows on from Head and Neck Cancer: an Evidence-Based Team Approach four years ago. It is a well-structured, up-to-date book in a readable layout with...
The 83rd book from the series by Advances in Oto-Rhino-Laryngology is another addition for the surgeon looking for an update in the management of hypopharyngeal carcinoma. The 180-page publication, divided into 16 chapters with 23 figures and 19 tables, has...
This randomised controlled trial aimed to establish the impact of prophylactic swallowing exercises in patients undergoing chemoradiation therapy for head and neck cancer. The primary outcome was the functional oral intake scale (FOIS), although secondary measures for feeding tube use,...
This paper presents a promising screening tool for oral cancer – using a simple chlorhexidine mouth-rinse. The hypermethylated ZNF582 and PAX1 markers were chosen based on previous studies using oral scraping methods of collection and have been shown to be...
The aetiological role of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OPSCC) is well established, and its incidence has massively increased over the last decade, whilst the incidence of HPV-negative OPSCC is declining. Although we know that HPV-positive OPSCC...
This edition of Head and Neck has a strong focus on studies using immunohistochemistry (IHC) to elucidate potential roles of various cell-signalling molecules in both HNSCC and thyroid cancer. The ‘cellular-protein heavy’ title of this article may be off-putting to...