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Interleukins, cilia and polyps
Interleukins (ILs) including IL13 (Th2 cytokine) are inflammatory mediators and their role in asthma has been detailed before. This study explores IL13 receptor expression in chronic rhinosinusitis with nasal polyps (CRSwNP). The authors investigate protein and mRNA expression levels of...
A review of significant issues in the management of obstructive sleep apnoea in children
There are considerable variations in the management of obstructive sleep apnoea in children and this suggests a need for more research and evidence-based information. In this review article, the authors address four key issues. Literature compares tonsillectomy with tonsillotomy, the...
Tinnitus in patients on therapy with PPI and in PPI non–users
Tinnitus is a chronic and debilitating condition and approximately 10% of the population is afflicted. A myriad of pharmacological treatments for tinnitus are available but only a few controlled studies have shown positive results. The relationship between proton pump inhibitors...
The relevance of rhinoplasty and septorhinoplasty from the commissioners
The rising costs of running the National Health Service and its overburdened resources has led to the constant monitoring of the low clinical value treatments. The operations of rhinoplasty and septorhinoplasty inevitably fall into this group and are subject to...
Information to support decision-making: does it make sense online?
The internet has become a major source for health information, with many people preferring to use the internet to search for advice than speaking to health professionals. Yet much of the information available is very difficult to read for the...
Medication and its effect on the larynx
This article summarises different medications and their effect on the voice. A growing number of patients we see in clinic are on multiple medications that could affect vocal cord function. The author summarises different classes of medications and their potential...
Genetic testing in congenital hearing loss
Advances in genetic testing over the last decade have reduced the cost and time such testing required and increased understanding of the genes involved in conditions like congenital hearing loss. This study from Atlanta looks at genetic testing from a...
Location, location, location: How to get the steroid where you need it, in chronic rhinosinusitis
What almost all current guidelines on chronic rhinosinusitis have in common is the importance of intranasal steroid (INCS) use. However, it is increasingly understood that the efficacy of INCS depends on their efficient delivery to the point of need, i.e....
Endovascular therapies for venous tinnitus
Tinnitus is an extremely vexing issue, not only for patients but also for otolaryngologists. The authors of this article review the causes of venous tinnitus, such as increased intracranial hypertension (IIH), dural venous sinus thrombosis and age-related anatomic variants. They...Share your perspective on improving reflux care pathways
BIOHIT HealthCare recently brought together leading ENT specialists and speech and language therapy professionals for a roundtable discussion on the complexities of diagnosing laryngopharyngeal reflux (LPR) and extraoesophageal reflux. Key themes included the lack of consensus around LPR as a...Medical and surgical management of performing vocalists
Dr Steven Zeitels is widely recognised as the foremost laryngologist of his generation. He has been at the forefront of innovation for 25 years, and has treated innumerable high-profile singers, most recently Sam Smith and Adele. Here, he gives us...
