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Genetics WG4. Improving diagnosis and drug development through the genetic understanding of tinnitus subtypes: a TINNET endeavour

Christopher R Cederroth and Jose Antonio Lopez-Escamez explain how progress is being made to investigate the contribution of genetic factors to tinnitus, including a subtype of ‘extreme’ tinnitus in Ménière’s disease. Genetics WG4 is working towards determining the genetic basis...

Medical Journals and The Journal of Laryngology and Otology

Medical journals have a fascinating history. One early journal, The Lancet, was founded in 1823 and its first Editor, London surgeon Thomas Wakley (1795-1862), had a turbulent life. He lived in an era where quackery was rife and where the...

Drug side-effects on audiological and vestibular testing

Are they a malingerer? Or perhaps they are inattentive? It may be their drugs! Robert DiSogra considers the side-effects of medication on the test subject. The audiogram serves many purposes in clinical practice. For the audiologist, it helps to differentiate...

Ear wax: the good, the bad, and the ugly

With ear wax removal being a core part of ENT and audiology services, Seth Schwartz gives us his dos and don’ts. We have all seen cartoons where a character pulls enough wax out of their ears to make a candle....

Paediatric ENT trauma

Managing trauma in children often strikes terror in doctors who do not deal with children regularly. Kate Stephenson explains the approach to a child who has suffered ENT trauma and specific things to look for in children. ENT injuries are...

Detecting postoperative cholesteatoma with diffusion weighted magnetic resonance imaging

Middle ear cleft cholesteatoma is an inflammatory disease that erodes local bony structures and can cause otorrhea, hearing loss, vertigo and intracranial complications. It is usually treated with surgery, typically canal wall up (CWU) or canal wall down (CWD) surgery....

How neuroimaging has changed our understanding of tinnitus

Brain imaging advances are revealing tinnitus-related neural networks, shedding light on its pathophysiology, heterogeneity and potential therapeutic targets. Tinnitus is a highly common but poorly understood disorder [1]. Its subjective nature and the fact that its treatment may span multiple...

Pre-clinical development of magnetic delivery of therapy to middle and inner ears

Why are we developing this technology? A key problem in drug delivery is getting the therapy to the right place in the body, which is especially challenging for targets that are small, deep and are protected or surrounded by anatomical...