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OTO-104 in noise-induced and cisplatin-induced hearing loss
These two animal studies report on potential new applications for intra-tympanic OTO-104, a slow-release hydrogel formulation of dexamethasone that is currently being used in a Europe-wide randomised trial for Ménière’s disease. In the first paper, guinea pigs were given a...
Temperature-controlled radiofrequency treatment of the nasal valve confers sustained benefit
Aiming to investigate long-term efficacy and safety (three years post treatment), this was an extension of a previous multicentre, prospective, single-blinded, randomised controlled trial that investigated the effectiveness and safety of temperature-controlled radiofrequency treatment (TCRF) to the nasal valve (NV)...
New MRI technique assesses treatment response in skull base osteomyelitis
This paper describes another useful imaging technique to monitor Necrotising Otitis Externa (NOE). Echoplanar diffusion weighted magnetic resonance (DW MR) shows high signal on the ‘ADC map’ with active disease and this reduces in signal intensity as symptoms improve. This...
Consider PCR testing in culture negative necrotising otitis externa
Necrotising otitis externa (NOE) often does not yield identification of a causative organism to treat although in 90% of cases it is a member of the pseudomonas species. The incidence of fungal NOE is not to be forgotten and this...
Management of necrotising otitis externa
Although uncommon, necrotising (previously malignant) otitis externa (nOE) can be very aggressive, particularly if not managed appropriately. In this study the authors perform a retrospective review of 25 patients admitted with nOE over a four year period at a tertiary...
How has management and outcomes of necrotising otitis externa changed over the past decade?
Necrotising otitis externa (NOE) remains a challenging condition for ENT departments, particularly with the increased prevalence of diabetes mellitus (DM) in the general population. There is no international consensus on treatment, although many institutions now have local guidelines drawn up...
Role of sentinel lymph node biopsy in managing papillary thyroid cancer
Although studies have shown that the presence of lymph nodes metastases in papillary thyroid carcinoma does not alter survival, other studies have shown that it increases morbidity and mortality and that the presence of cervical lymph node metastasis at diagnosis...A new approach to workplace hearing conservation
The traditional approach to managing workplace noise has failed - how can we better protect our nation’s hearing using smart hearing protection? Occupational noise-induced hearing loss (ONIHL) is the most common occupational health condition in the world and the most...
Lymph node ratio in tongue cancer
This is an analysis of 88 patients treated in Switzerland between 2003 and 2012. All patients had a selective neck dissection and recurrence occurred in 25 patients. Overall and disease specific survival were 72% and 80%. They specifically looked at...
Noise induced hearing loss caused by nightclubs
Legislation on hearing loss and tinnitus, occurring due to noise exposure at work, has been well established in terms of protection and compensation, but the same damage resulting from noise in nightclubs remains an open issue. This study, based on...
Do personal listening devices cause cochlear synaptopathy?
Cochlear synaptopathy is a condition in which noise interrupts the synaptic communication between sensory inner hair cells and low spontaneous rate cochlear nerve fibres. Since these nerve fibres are associated with signal coding in noisy backgrounds, their disruption leads to...
