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Interleukins, cilia and polyps

Interleukins (ILs) including IL13 (Th2 cytokine) are inflammatory mediators and their role in asthma has been detailed before. This study explores IL13 receptor expression in chronic rhinosinusitis with nasal polyps (CRSwNP). The authors investigate protein and mRNA expression levels of...

Multisystem pathology in refractory otitis media with effusion

Recurrent middle ear effusion is a common problem and so is rhinosinusitis with polyposis. It is not often thought that the problem could be linked to multisystem pathology, such as eosinophilic granulomatous with polyposis. Therefore, repeated grommet insertions and surgical...

More aggressive FESS for recalcitrant CRS is the key

This is an interesting paper assessing the effectiveness of endoscopic modified medial maxillectomy (MMM) in cases of recalcitrant chronic rhinosinusitis (CRS), (the technique was also used for tumours, cystic fibrosis, FB, odontogenic disease and AFS) in 551 patients. The technique...

Comparison of outcomes after septoplasty

For this prospective study, the authors assessed the quality of life (QoL) with the rhinosinusitis SNOT-20 (Sino-Nasal Outcome Test-20) questionnaire and the symptoms on a visual analogue scale (VAS) in all patients undergoing nasal septal surgery. The patients reported the...

Balloon dilatation is an effective adjunct

This is a good study design, sufficiently powered, comparing medical management to balloon sinus dilatation. All patients had failed medical management and were thoroughly assessed preoperatively with Lund-Mackay score confirming abnormal CT findings, SNOT 20 index score, chronic sinusitis score...

Outcomes in endoscopic sinus surgery

This study assessed the effect of endoscopic sinus surgery with regard to olfactory function and nasal obstruction, in chronic rhinosinusitis (CRS) patients with, and without, nasal polyposis. One hundred and thirteen patients entered the study, and assessments were performed pre-...

A review of endoscopic sinus surgery outcomes

This review discusses the outcome measures that may be considered in the assessment of patients with chronic rhinosinusitis (CRS) as well as the outcomes of endoscopic sinus surgery (ESS) published so far. The authors also discuss the role of peri-operative...

ChatGPT to select patients for biologic therapies in CRSwNP?

This short communication describes programming the artificial intelligence (AI) algorithm for systematic review of current literature about guidelines on the clinical efficacy and safety of biologics in the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP). The authors first performed...