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The search for the holy grail of rhinosinusitis: another step towards phenotyping in CRS wNP?
For many years, scientists and clinicians have been trying to understand the infinite variability within the term ‘rhinosinusitis’ using radiology, basic science, epidemiology and then using their insights to solve the riddle of management: how to explain why some patients...
Can we predict how much benefit patients will get from ESS with a novel monoclonal antibody
Mepolizumab (Nucala) is a humanised IgG1 monoclonal antibody that acts as an IL-5 antagonist. It has been shown to be highly effective in treating severe asthma. It is hypothesised that it will be effective for patients with recalcitrant CRSwNP. This...A place for everything and everything in its place: the practicalities of randomised clinical trials
Will this pill cure tinnitus? Bonnie Millar describes one trial that has investigated the possibility whilst describing the path of drug trials in the UK. Background In the last quarter of 2014, a clinical trial (QUIET-1; ClinicalTrials.gov Identifier: NCT02315508) commenced...Digital otoscopy with AI diagnostic support: making diagnosis of ear disease more accessible
Following Carolina Leal’s interview with Prof De Wet Swanepoel on the HearScope system, Spotlight on Innovation asked Dr Jenny Nesgaard Pedersen to review the new AI feature in HearScope system’s capabilities. In the last decade, artificial intelligence (AI) and machine...Hyposalivation: a review of current and future treatments
Hyposalivation remains a stubbornly difficult condition to treat, but novel therapies may not be far away. Saliva has many essential functions, including aiding digestion and swallowing, lubrication, maintaining tooth integrity and antibacterial activity. When patients experience reduced saliva production (hyposalivation),...Changing the face of global health: short-term surgical trips
With the growth of global health awareness, global surgery has emerged as a key focus area. This article examines short-term surgical trips (STSTs) as one of the ways used to address some of the gaps in global surgery. It demonstrates...
Novel wax solvent
This paper describes an open label, prospective study undertaken by the authors to demonstrate the safety and efficacy of a novel topical wax solvent. This new product has a dual action using a bicarbonate system to disrupt the esters and...
IL-25 and nasal polyps, another target
Immune response in chronic rhinosinusitis with nasal polyps (CRSwNP) is mainly via type 2 T-helper (Th2) cells while Th1 cells characterise chronic rhinosinusitis without nasal polyps (CRSsNP) immune response. CRSwNP is heterogeneous on a cytological level causing a varied response...
Aerosols and polypi
Infection in the operative cavities after endoscopic sinus surgery for sinonasal polyposis leads to recurrence of symptoms and mucopurulent discharge. The usual therapies include systemic antibiotics sometimes with steroids. The authors hypothesised that the use of a topical antimicrobial (tobramycin...
N-acetylcysteine may have a role in the protection of cochlear hair cells
Gentamycin is an aminoglycoside antibiotic which is widely used throughout the world, despite its ototoxic potential. It therefore seems wise to continue the search for accessible otoprotective agents. The aim of this study was to clarify the potential protective role...
Postinfectious olfactory disorders
Recovery of olfactory function following URTI is frequent, even many years after the infectious insult. Upper respiratory tract infection is the commonest cause of olfactory loss. Many treatment options exist including topical steroids, vitamin B, acupuncture, and zinc, which can...
