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Mapping the financial and disease burden of hearing loss and associated interventions
The prevalence and burden of ear and hearing disorders is huge and, historically, has been underappreciated. Globally, unaddressed hearing loss poses a growing public health challenge, requiring urgent attention from policymakers, health professionals and civil society. The recently published World...
Allergen specific subcutaneous immunotherapy helps in prolonged control of allergic rhinitis
One of the commonest allergens involved in perennial allergic rhinitis is house dust mite. A good proportion of these cases prove intractable to treatment with oral and intranasal antihistamines and intranasal steroid sprays. Immunotherapy is considered a useful alternative and...
The stubborn polyp cases are ‘different’
The widely different behaviour of nasal polyp disease between patients is a major feature of rhinology practice and makes counselling of patients difficult when approaching their first operative intervention. Setting aside aspirin sensitivity (Samter’s triad), which is known to be...
A new era in the treatment of recalcitrant nasal polyps?
Chronic rhinosinusitis with nasal polyps (CRSwNP) can be difficult to treat effectively in patients with aggressive or recalcitrant disease. Omalizumab (Xolair) is a monoclonal anti-IgE antibody with proven benefits for patients with moderate/severe asthma and CRSwNP, but this study looks...
Serum biomarkers for CRSwNP
This cross-sectional comparative study looked at 50 patients with nasal polyps who, at the time of diagnosis, also had a blood test evaluating serum total IgE, IL-17 and Pentraxin-3. The study assesses whether these blood markers are useful in the...
The future of biologics?
This paper takes a deep dive into how eosinophilia affects the responsiveness of the host to the two monoclonal antibodies mepolizumab and bendralizumab, both of which are active against IL5. We know that eosinophils are attracted and trapped into the...The Indian method: Sushruta’s influence on modern nasal reconstruction
Ancient Indian medicine, as documented in the Sushruta Samhita, contains one of the earliest known references to nasal reconstruction, including surgical techniques still resembling modern practices. (The Sanskrit word ‘Samhita’ is used to define a collection of written work, similar...The effects of polypharmacy in the elderly
Another pill to cure the ill? Alec Lapira discusses the warning signs of polypharmacy in the elderly population. Polypharmacy in the elderly Polypharmacy – defined as the use of five or more medications – occurs in 20–37% of older people...
Red flags in the development of childhood speech and language
Problems of speech and language in early childhood can influence a child’s emotional development, academic prowess and quality of life. This article is a consensus report from the Netherlands describing 124 clinical signs and 34 red flags of atypical speech...
Factors determining success of adenotonsillectomy in paediatric obstructive sleep apnoea
Patient selection is important for any successful surgical procedure. Adenotonsillectomy for obstructive sleep apnoea secondary to adenotonsillar hypertrophy is no exception. This retrospective Taiwanese study attempts to find preoperative factors that have a positive influence for this commonly performed operation....
Relationship between early language delays and long-term outcomes
This epidemiological study from Australia, spanning 16 years, explores the influence of early language delays over time on outcomes in affected adults. Based on vocabulary skills at age five, the study population was classified into four groups: persistently good, persistently...
