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Serum biomarkers for CRSwNP

This cross-sectional comparative study looked at 50 patients with nasal polyps who, at the time of diagnosis, also had a blood test evaluating serum total IgE, IL-17 and Pentraxin-3. The study assesses whether these blood markers are useful in the...

The future of biologics?

This paper takes a deep dive into how eosinophilia affects the responsiveness of the host to the two monoclonal antibodies mepolizumab and bendralizumab, both of which are active against IL5. We know that eosinophils are attracted and trapped into the...

Red flags in the development of childhood speech and language

Problems of speech and language in early childhood can influence a child’s emotional development, academic prowess and quality of life. This article is a consensus report from the Netherlands describing 124 clinical signs and 34 red flags of atypical speech...

Factors determining success of adenotonsillectomy in paediatric obstructive sleep apnoea

Patient selection is important for any successful surgical procedure. Adenotonsillectomy for obstructive sleep apnoea secondary to adenotonsillar hypertrophy is no exception. This retrospective Taiwanese study attempts to find preoperative factors that have a positive influence for this commonly performed operation....

Relationship between early language delays and long-term outcomes

This epidemiological study from Australia, spanning 16 years, explores the influence of early language delays over time on outcomes in affected adults. Based on vocabulary skills at age five, the study population was classified into four groups: persistently good, persistently...

Association of childhood OME with obesity

Many factors influence the development of otitis media with effusion (OME) in children, some of them being increased plasminogen factor inhibitor (PAI-1) levels, eustachian tube obstruction and gastro-oesophageal reflux. These factors are also associated with obesity. Sixty children with mean...

Division of tongue tie helps breast feeding

The need for frenotomy in children with tongue tie is not universally accepted. It is however understood that among other problems, such as impaired speech, tongue tie impedes breast feeding possibly leading to early weaning. Therefore, with recent resurgence of...

Puberty and rhinitis

While asthma and rhinitis are more common in boys compared to girls in childhood, whether this trend persists after puberty or not is not yet clear. Authors inspected the European Commission funded MeDALL (Mechanisms of the Development of ALLergy) to...

Should all patients with BPPV have an MRI?

This paper describes an interesting series of 500 patients over a 10-year period with posterior canal BPPV, who had been investigated with MRI. The female to male ratio was 1.6:1 with a mean age of 56. There was a right...

Maturation of BC attenuation

The aim of this study was to clarify the reason for differences between bone-conduction hearing in adults and infants. The authors investigated how the sound pressure level in the ear canal changes depending on the bone-conduction transducer placement. By using...

Thyroid nodule update

This excellent article summarises the current diagnostic difficulties with an endocrine gland that frequently produces nodules, some of which may harbour malignancy. At 50 years of age and over there is about a 50% chance of having a nodule; at...