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New aminoglycosides with reduced ototoxicity risk
Aminoglycoside antibiotics are widely used for infections affecting patients of all ages and at different sites, however they carry a risk of ototoxicity, nephrotoxicity and rarely peripheral neuropathy. Preventing ototoxicity is crucial to the maintenance of auditory function and quality...
Clival chordoma recurrence
Chordomas are generally slow growing and are histologically considered low grade tumours. Their high recurrence rate even after postoperative radiation renders them difficult to treat. This is particularly true for clival chordomas whose deep anatomic location and proximity to vital...
Long-term outcomes after endoscopic pituitary macroadenomas resection
In this retrospective study the authors attempted to find out long-term outcomes after pituitary macroadenoma resection via the endonasal endoscopic transsphenoidal route. Eighty of the 162 patients operated on met the study criteria of clinical and radiological follow-up for at...
Lipofilling for scar improvement
Since Coleman et al. in 1991 reported on lipofilling, numerous applications have been reported; these include but are not limited to contour restoration, lip augmentation, and wrinkle therapy. There has also been some one off reported improvements in scars following...
Resection margins in head and neck surgery
Although an increasing proportion of head and neck malignancies are treated with non-surgical modalities, when surgery is undertaken an incomplete clearance results in significantly worse prognosis. However, the intraoperative assessment of an adequate margin is difficult. The personal practice of...
Improving smell outcomes after sinus surgery: impregnated dressings?
There is much we can do to improve the airway of patients with chronic sinus disease, especially those with polyps. However, the olfactory outcomes are usually disappointing and patients miss this important sensory modality, which has an effect on their...
Questionnaire to determine quality of life in Parkinson’s disease patients with swallowing problems
The quality of life (QoL) in individuals with Parkinson’s disease (PD) is often influenced by changes in their swallowing abilities. The authors of this paper have developed a valid, statistically appropriate questionnaire which is also clinically effective and can be...
Rib grafts for mandibular reconstruction
Reconstruction of the mandible following ablation requires good bone stock to allow optimal function and the placement of dental implants. In the developed world, vascularised bony flaps are accepted as the gold standard but these may not be widely available...
