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Hearing loss and Alport syndrome
Alport syndrome (AS) includes a group of hereditary diseases caused by mutations in the COL4A3, COL4A4 or COL4A5 genes. These genes are responsible for the biosynthesis of α3, α4 and α5 collagen IV chains, which are located in the glomerular...Dr Marion Pfaender Down
“Dr Marion P Downs, an innovator in the field of paediatric audiology and a tireless advocate for the early identification of hearing loss, passed away on November 13, 2014. During her exemplary career at the University of Colorado Health Sciences...
Paediatric pain control post-tonsillectomy
The use of codeine in the paediatric population is widely debated since the American Food and Drug Administration (FDA) published warnings regarding overdose and death following the usage of codeine. Codeine is metabolised by the polymorphic cytochrome PY4502D6 (CYP2D6) in...
Surgical indications for infantile haemangiomas
Infantile haemangiomas are embryonal tumours and represent the most common tumour of infancy, with an estimated incidence 4-5%. There is well-described natural history, usually becoming apparent in the first few weeks of life and proliferating rapidly in the first few...Surgical management of sleep disordered breathing
Snoring and sleep-disordered breathing are often described as multi-level problems, and different surgical procedures are required to treat the various sites of airway narrowing and/or collapse. Jonathan Hobson gives us an eloquent run-through the various options available to the ENT...In conversation with Professor Charles Liberman
Just before I left Cambridge to work with the Hearing Sciences group in Nottingham, I spent a very happy hour alone in the company of Professor Charles Liberman, the Director of the Eaton-Peabody Laboratories based at the Massachusetts Eye and...Audiology Training – Time to change our Spots? A student’s perspective of the Scientist Training Programme
In the “Just-so Stories”, the accomplished wordsmith Rudyard Kipling details how the leopard got his spots. Which concludes that the leopard will never change his appearance again as he is quite content just the way he is. The former degree...
Canal wall down with obliteration of cavity for paediatric cholesteatoma
The authors present evidence that canal wall down (CWD) surgery with primary obliteration is an effective way to treat paediatric cholesteatoma. Fifty-eight ears were operated on and follow-up was for five years on average. Residual cholesteatoma rate was 9.9% with...
