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Endotypes in chronic rhinosinusitis: clinical relevance

3 May 2024 | | ENT, Rhinology / Sinus
Identifying endotypes enables personalized therapies that target specific pathophysiological processes, potentially resulting in better treatment outcomes for patients. The contemporary model of chronic rhinosinusitis (CRS) pathogenesis revolving around endotype, in combination with an expanding toolbox of diagnostics and therapeutics, enables...

Biologic therapies for chronic rhinosinusitis with nasal polyps: a new paradigm

5 July 2022 | | ENT, Rhinology / Sinus
Surgery for nasal polyposis has evolved significantly in the last 30 years, and now the medical management may be on the cusp of a revolution. Biologics using monoclonal antibodies to target specific immune pathways have introduced a paradigm shift in...

In conversation with Dr Naufal Kassim

1 March 2014 | | Audiology - Paediatric, Audiology - Diagnostic, ENT, Audiology - Adult, Otology, Paediatric ENT
Jane and I first met you six years ago, when we were questioning the apparent high incidence of childhood deafness in Tanzania, and it is a real pleasure doing this interview with you. Your contribution to ENT and general health...
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CRSwNP, another monoclonal antibody

1 July 2019 | | Rhinology / Sinus | biomarkers, dupilumab, nasal polyposis, nasal secretions, type 2 inflammation
Interleukins 4, 5 and 13 were shown to be important factors in type 2 inflammation, which characterises chronic rhinosinusitis with nasal polyposis (CRSwNP). In CRSwNP non-responders and those who recur short after-surgery monoclonal antibodies might be an answer. Examples include...

Gardasil vaccination as an adjuvant treatment for established recurrent laryngeal papillomatosis in male adults - does it stimulate an immune response?

1 May 2017 | | Gardasil, antibody titers, quadrivalent HPV vaccine, ecurrent laryngeal papilloma, recurrent respiratory papillomatosis
Recurrent respiratory papillomatosis (RRP) is well known to be caused by infection with the human papilloma virus (types 6 and 11). Recurrence after surgical removal is common and potentially frequent and severe. Previous research has established that many patients with...

Bringing ear care and hearing services to the hardest to reach: the potential of primary healthcare workers

4 May 2021 | | Audiology - Adult, Otology
Can workers from the local community plug the workforce gap in providing ear and hearing care? Bringing ear and hearing care services closer to the community remains a key component of reducing the burden of ear and hearing conditions across...

Bringing ear care and hearing services to the hardest to reach: the potential of primary healthcare workers

4 May 2021 | | Audiology - Adult, Otology
Can workers from the local community plug the workforce gap in providing ear and hearing care? Bringing ear and hearing care services closer to the community remains a key component of reducing the burden of ear and hearing conditions across...

Pre-clinical development of magnetic delivery of therapy to middle and inner ears

1 March 2014 | | ENT, Otology
Why are we developing this technology? A key problem in drug delivery is getting the therapy to the right place in the body, which is especially challenging for targets that are small, deep and are protected or surrounded by anatomical...

Anaesthesia for free-flap surgery

1 November 2019 | | ENT
Adel Hutchinson is one of those calm and controlled anaesthetists for whom nothing seems too difficult. In this article, she describes the key perioperative factors for one of the highest complexity operations in ENT; free-flap surgery. It makes good reading...

Endoscopic excision of cholesteatoma

1 November 2019 | | ENT, Otology
In this article Vikranth Visvanathan describes an exciting development on the use of endoscopic technology in complex otological practice. Transcanal endoscopic ear surgery (TEES) is rapidly evolving as a recognised method of addressing middle ear and mastoid pathology. Since its...

Pinnaplasty for prominent ears

9 September 2020 | | ENT, Paediatric ENT
Pinnaplasty is a challenging yet rewarding procedure for which many different techniques have been described. In this article the authors describe their favoured technique, including the important postoperative care. Prominent ears can be a source of significant psychological distress in...

What’s in a name?

1 March 2016 |
Kate Granger is a doctor and the founder of the #hellomynameis campaign; she is also a cancer patient. In this article she explains why she started the campaign, and why patient-centred care starts with an introduction. Chris and me the...