You searched for "genes"

995 results found

Vestibular functions of hereditary hearing loss patients with GJB2 mutations

Mutations of the GJB2 gene are a common cause of deafness, being found in 15-25% of cases of congenital deafness. Over 100 mutations are now recognised and may be associated with a hearing loss ranging from mild to profound. This...

A higher aspiration for fine needles

Fine needle aspiration biopsy (FNAB) has aided in the diagnosis and management of thyroid nodules for decades. Now a rapid evolution is hoped to benefit an increasing cohort of patients with small nodules and non-diagnostic investigations. This review discusses the...

Those little friends in our noses

Human microbiota plays an important role in both health and disease including metabolism, immunomodulation, and a potential role in chronic inflammatory conditions such as chronic rhinosinusitis (CRS). The authors aimed to investigate the sinonasal microbiome using 16S rRNA gene sequencing...

Age and sleep disorders as risk factors for Ménière’s disease

Decades after it was first described, the pathophysiology of Ménière’s disease is still a subject for research and discussion, with several controversies regarding its management. Several factors have been reported to cause Ménière’s disease including viral infections, allergies, genetic factors,...

On the shoulders of giants: a reflection on Wolfgang Steiner

Professor Wolfgang Steiner. Wolfgang Steiner inspired a whole generation of head and neck surgeons. Terry Jones gives us his own personal perspective. “We are like dwarfs on the shoulders of giants, so that we can see more than they, and...

Thyroidectomy patient survey regarding voice outcomes

One of the common adverse effects following thyroid surgery is a change in voice, which may be related to iatrogenic injury to the recurrent laryngeal nerve or superior laryngeal nerve during surgery or by direct cancer involvement. The burden of...

Systemic agents in thyroid cancer

For those patients who have disseminated or unresectable thyroid cancer, Dr Arabella Hunt and Dr Kate Newbold review systemic treatments, their differences, toxicities and outcomes. Thyroid cancer is the most common endocrine malignancy. It is subdivided into differentiated (papillary, follicular...

Managing high flow head and neck arteriovenous malformations (AVM)

Vascular malformations are lesions where the traditional network of capillaries linking arteries and veins are lacking. Patients usually present with bleeding, pain, disfigurement and tissue expansion and destruction. High flow lesions can be challenging to manage in the head and...

Cochlear implantation in the developing world: perspectives from the Indian subcontinent

Cochlear implants are an expensive technology, yet profound hearing loss is far from a developed-world phenomenon. On the contrary, incidences of both congenital and acquired hearing losses are high in the developing world. This article explains how an initiative in...

The effects of hormonal changes across menstrual cycle on high frequency auditory thresholds

Physiological changes during the menstrual cycle are well documented; do these changes extend to the auditory system? Lalsa Shilpa Perepa and Rewa Indurkar delve into the literature to find the evidence. Menstrual cycle refers to a series of changes that...

Founding of International Association of TransVoice Surgeons

World renowned laryngologists and voice surgeons have joined forces to improve the quality of voice care for the transgender community.

Effect of age-related changes in voice production and hearing on Voice Handicap Index and Geriatric Depression Scores

The ageing process affects hearing and production of voice. It is not unknown that impairment of these faculties can affect quality of life and also cause depression. The authors have presented an array of actual anatomical and functional changes that...