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The structure and function of DNA

DNA structure and replication Genetic information within multicellular organisms, including man, is stored in molecules of deoxyribonucleic acid (DNA), which reside within the chromosomes of each cell nucleus. A DNA molecule consists of two very long chains, or strands, of...

Surgical management of sleep disordered breathing

Snoring and sleep-disordered breathing are often described as multi-level problems, and different surgical procedures are required to treat the various sites of airway narrowing and/or collapse. Jonathan Hobson gives us an eloquent run-through the various options available to the ENT...

The MACRO Trial: defining best management of chronic rhinosinusitis

A major UK trial in The Lancet finds ESS provides greater symptom relief than long-term macrolides for adults with CRS, supporting earlier surgery and fewer antibiotics. The MACRO Programme was established in 2016 when the UK National Institute of Health...

Per-Ingvar Brånemark: father of osseointegration

The application of osseointegration has been central to the development of both bone-anchored hearing aids and dental implants. But how did it all come about? Per-Ingvar Brånemark (1929–2014). Image Johan Wingborg. Many hearing-impaired patients owe a great debt of gratitude...

What has NAIROS taught us about septoplasty?

Septoplasty is a commonly performed procedure worldwide for nasal obstruction associated with a deviated nasal septum. In the UK, with long waiting lists for septoplasty, there is a large and unexplained variation in the incidence of this procedure between individual...

First UK Genio Nyxoah bilateral hypoglossal nerve stimulator implant for obstructive sleep apnoea

Obstructive sleep apnoea remains a very challenging condition to treat, but more options are becoming available. An estimated eight million adults in the UK suffer from obstructive sleep apnoea (OSA) and experience symptoms of troublesome snoring, daytime sleepiness and witnessed...

Audiological and psychological consequences of single-sided deafness

The loss of sound input from one ear has a significant impact on our perception of our acoustic environment. This impact is compounded in adverse listening conditions. Rachel Knappett’s article explores the audiological impact of this hearing loss and the...

Assessing dizziness-related quality of life in the paediatric population

In this article, Devin McCaslin and Gary Jacobson share their experience of assessing dizziness-related quality of life in paediatric patients, and demonstrate that the involvement of care-givers is vital in ensuring the most appropriate assessment and treatment for this particular...

A place for everything and everything in its place: the practicalities of randomised clinical trials

Will this pill cure tinnitus? Bonnie Millar describes one trial that has investigated the possibility whilst describing the path of drug trials in the UK. Background In the last quarter of 2014, a clinical trial (QUIET-1; ClinicalTrials.gov Identifier: NCT02315508) commenced...