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Diagnosis of obstructive sleep apnoea hypopneoa syndrome (OSAHS) without sleep studies
Polysomnography is considered the ‘gold standard’ in the diagnosis of sleep apnoea but it is expensive and difficult to perform in children. Diagnosis based on subjective judgement is often inaccurate. An accurate diagnostic scale based on clinical parameters could obviate...
Follicle stimulating hormone receptors; an aid for the pathologist?
It is well known that Follicle Stimulating Hormone receptors (FSHRs) are found in extra-gonadal tumours such as those within thyroid tissue. This Polish study analysed 44 thyroid resection specimens to look for the presence of these receptors. No mention is...
Paediatric pain control post-tonsillectomy
The use of codeine in the paediatric population is widely debated since the American Food and Drug Administration (FDA) published warnings regarding overdose and death following the usage of codeine. Codeine is metabolised by the polymorphic cytochrome PY4502D6 (CYP2D6) in...
Predicting outcomes in rhinology using fluid dynamic models
This article discusses the rhinological applications of computational fluid dynamics (CFD) – a method derived from engineering applications, such as aerodynamics. Its appeal is that it can provide simulated data on airflow velocity, pressure, resistance, temperature, humidity, heat flux and...
Eosinophilic or not eosinophilic: dupilumab seems to work
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammation with interleukin (IL)-4, IL-13, and IL-5. Tissue eosinophilia in nasal polyps dramatically increased over a 10-20-year period. Classification of the severity of eosinophil status is expected to lead to...
