You searched for "genomics"

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In memory of Robert Allan Yorston (10th March 1920 – 1st October 2016)

In this special feature article, Alan Gibb writes a touching tribute to his friend and colleague Dr Bob Yorston, a Dundee otolaryngologist, who had a special talent for humour and art. In addition to illustrating the eighth, ninth and tenth...

Identifying congenital CMV: the screening debate

Congenital cytomegalovirus (cCMV) is a significant global public health burden and is the biggest non-genetic cause of childhood hearing loss, as well as being an important cause of neurodevelopmental delay. Despite a study concluding that there was not enough evidence...

In conversation with Dr John Woo and Mr Derek Skinner

Dr John Woo and Mr Derek Skinner have between them an absolute wealth of experience and expertise in the fields of surgical training and specialist examinations. Here, they tell us about their involvement in surgical education, and explain some of...

The MACRO Trial: defining best management of chronic rhinosinusitis

A major UK trial in The Lancet finds ESS provides greater symptom relief than long-term macrolides for adults with CRS, supporting earlier surgery and fewer antibiotics. The MACRO Programme was established in 2016 when the UK National Institute of Health...

Ballenger’s Otorhinolaryngology: Head and Neck Surgery, 18th Edition

One hundred and eight years after its first edition, the two-volume eighteenth edition of Ballenger’s Otorhinolaryngology is published in1300 pages set out in six sections, 114 chapters ably edited by Ashley Wackym and James Snow. Volume one very comprehensively covers...

Manual of Pediatric Balance Disorders - Second Edition

This is a very welcome and recently updated book for those wishing to learn about paediatric balance disorders. It has a multidisciplinary authorship and therefore all the specialties involved in the management of a child with balance problems should be...

Textbook of Otitis Media: The Basics and Beyond

This book is a comprehensive resource that discusses the multifaceted condition of otitis media. It aims to serve a wide range of medical professionals, including otolaryngologists, audiologists, paediatricians, and medical students, by providing both fundamental knowledge and advanced insights into...

Clinicopathological features of follicular variant of papillary thyroid carcinoma

The follicular variant (FV) of papillary thyroid carcinoma (PTC) is characterised by the presence of nuclear features of PTC together with a follicular growth pattern. It is currently reported to make up 11.8% to 53.3% of all PTC cases. It...

Recurrent ENT infections in children – is it a sign of primary immunodeficiency disease?

ENT clinicians often come across children with recurrent ear, sinus and pulmonary infections. These recurrent infections, albeit common in childhood, can represent an early sign of primary immunodeficiency diseases (PIDD). PIDD is an underdiagnosed group of genetic disorders involving absent...

The polyp shrinker

Inflammatory markers, including T2 cells beta common (βc) cytokines IL-3, IL5 and granulocyte-macrophage colony-stimulating factor (GM-CSF), are known to play an important role in chronic rhinosinusitis with nasal polyps (CRSwNP). CSL311, a monoclonal antibody (mAb), was developed to target human...

Improving music perception in cochlear implant users

Can you imagine a world without music? In the words of Hans Christian Anderson, a prolific 19th-century Danish author, “Where words fail, music speaks.” This quote highlights music’s importance as a language of emotions that transcends linguistic barriers. This case...

Hearing loss and Alport syndrome

Alport syndrome (AS) includes a group of hereditary diseases caused by mutations in the COL4A3, COL4A4 or COL4A5 genes. These genes are responsible for the biosynthesis of α3, α4 and α5 collagen IV chains, which are located in the glomerular...