You searched for "molecular"
Immunosuppresants and ototoxicity
There is a wide range of immunosuppressant drugs ranging from calcineurin inhibitors (e.g. cyclosporine), anti-folic agents (e.g. methotrexate) to anti-TNF and monoclonal antibodies, many of which could be ototoxic. The authors performed a systematic review assessing ototoxicity secondary to immunosuppressant...
How reliable is non-echoplanar diffusion-weighted MRI in picking up postoperative cholesteatoma in children?
Cholesteatoma occurs more often in children than in adults and is more aggressive, often resulting in ossicular erosion and marked conductive loss, amongst other more serious possibilities. Recurrence happens in all three methods used, namely canal wall up, canal wall...Middle ear reconstruction in children: why, when and how
Every ear in every child is different. Rob Nash discusses the rationale behind reconstructive ear surgery in children and his philosophy on timing and techniques of reconstruction. It is rare for middle ear pathologies to be life threatening. Indeed, it...
Posterior TM perforations carry greater hearing loss: practical pointers for clinic
This single-centre prospective study of 100 adults with central pars tensa perforations examined how perforation size and quadrant relate to hearing loss. Using video-otoscopy to estimate perforation area and pure tone audiometry for thresholds, the authors found hearing loss in...Middle ear muscle disorders: presentation, diagnosis and management
Patients often report symptoms relating to disorders of the middle ear muscles. Prof Bance gives us an overview of the anatomy and function, as well as guides our diagnosis and management. The middle ear muscles (MEMs) are a mystery, both...Should human beings sleep in the prone position?
Are we poised for a ‘sleep prone’ campaign to reduce nocturnal apnoeas? Prof Armin Moniri presents a fascinating account of how sleeping position can affect obstructive sleep apnoea. Inspired by sleeping position of other mammals, a new mattress and pillow...Adolescence, drug use and body image
Teenagers are notoriously conscious of how they are perceived by others. Dr Saraiva and colleagues explain how this can lead to problems with substance abuse for both boys and girls, and discuss the different substances they may encounter. Adolescence is...Non-absorbable synthetic material for middle fossa repair using a combined transmastoid/middle fossa approach
Repair of CSF leaks can be a challenging technical undertaking. In this article, the authors describe their use of a synthetic material to help with the successful repair of these leaks from the middle cranial fossa. Erosion of the middle...Impact of outer ear problems in Northern Ethiopia: experiences of a global outreach clinic
Outer ear disease is one of the commonest reasons for attending the ENT clinic in Ethiopia, just as in the UK. Very little has been published on the experiences of ENT clinics in Ethiopia. Here Yilkal Tassew, Seid Temam and...Temporal bone trauma
Introduction Temporal bone injuries represent one of the more complex management problems presenting to the otolaryngologist. This is largely due to difficulties in assessment and the frequent delays in referral, often as a result of other injuries demanding more immediate...
Surgical management of permanent facial paralysis
This article explores the management of flaccid facial palsy focusing on weakness less than one to two years’ duration. As a general rule, primary nerve repair produces the best outcome and should be performed where possible. For long-standing paralysis of...
