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The search for pharmacological treatments for hearing loss and tinnitus

Where are we in our search for a hearing restoration grail? Nicola Robas leads us through the map pieces discovered in creating a pharmaceutical answer to hearing loss and tinnitus. Together, hearing loss and tinnitus affect over one in six...

Precision and personalised genomic and epigenomic medicine in audiology/hearing loss

A detailed look at the pathogenesis of acquired hearing loss due to exposure to ototoxicity during pregnancy or shortly after birth. Insights from genomic medicine have shown that, along with environmental factors causing epigenetic alterations, hearing loss may be caused...

Otological problems in musicians

Musicians are understandably anxious about their hearing, and recent high-profile cases of noise-related hearing loss have resulted in huge changes in the music industry. Chris Aldren (otologist and violinist) explains. In the recent Oscar-winning movie, Sound of Metal, heavy metal...

Human immunodeficiency virus and hearing impairment

With an estimated 36.7 million individuals living with HIV / AIDS and literature reporting that these conditions contribute to hearing loss, it is surprising that more focus and resources are not employed to tackle this major hearing health concern. Yolandé...

Laryngeal transplantation: is it a thing?

Few organs could be said to be more complex than the larynx when it comes to transplantation. Martin Birchall looks at past challenges, current issues and future prospects. I am not clear exactly why I chose to spend a life...

The structure and function of DNA

DNA structure and replication Genetic information within multicellular organisms, including man, is stored in molecules of deoxyribonucleic acid (DNA), which reside within the chromosomes of each cell nucleus. A DNA molecule consists of two very long chains, or strands, of...

In search of courage; transition 
into Army

In search of courage. Well, that is how it all started. I was fairly advanced in surgical training not to mention age, when I decided to join the Territorial Army (TA). My peers, on hearing this couldn’t decide whether I...

Guillotines from Joseph‑Ignace Guillotin to Greenfield Sluder

Joseph‑Ignace Guillotin. The politician and physician Joseph-Ignace Guillotin (1738-1814) was so disgusted by brutal head and shoulder injuries sustained in ‘failed attempts’ by drunken axe-wielding executioners during the French Revolution that he and surgeon Antoine Louis (1723-1792) advocated not only...

Surgical technology and operating room safety failures: lessons from vascular and general surgery

Background – surgical technology and otolaryngology An estimated 234 million major surgical procedures are performed annually worldwide. This requires the interaction of multidisciplinary teams with varying contributions of surgical technology and therefore makes surgical procedures prone to multiple sources of...

Audiological evaluation and management of teenagers with tinnitus

There is a growing interest in investigating, understanding and managing tinnitus in children and adolescents, with several articles on the subject published in journals over the last year. Brian Fligor describes the approaches to consider when discussing tinnitus with teenagers....

Robotic surgery for squamous cell cancer: the new frontiers

Although the da Vinci platform was FDA approved for early-stage oropharyngeal cancers, the indications have expanded. In this article, John Hardman explains how surgeons, with greater understanding of the strengths and limitations of robotic surgery, have systematically set out to...