You searched for "genetic"

1445 results found

Systemic agents in thyroid cancer

For those patients who have disseminated or unresectable thyroid cancer, Dr Arabella Hunt and Dr Kate Newbold review systemic treatments, their differences, toxicities and outcomes. Thyroid cancer is the most common endocrine malignancy. It is subdivided into differentiated (papillary, follicular...

Videofluoroscopic swallowing studies: balancing risks and benefits

Videofluoroscopic swallow studies (VFSS) are an important part of the diagnostic toolkit and arguably the current gold-standard for assessing swallow biomechanics and diagnosing dysphagia. However, the procedure does involve exposure to radiation, and any clinician requesting this should be able...

The Laryngeal Pacemaker – developing an innovative solution for bilateral vocal fold paralysis

Bilateral vocal fold paralysis is a difficult condition to manage, with surgical interventions previously limited to tracheostomy or arytenoidectomy. Re-innervation surgery has been developed and, in recent years, a Laryngeal Pacemaker is now in clinical trials. We speak to two...

The Laryngeal Pacemaker – developing an innovative solution for bilateral vocal fold paralysis

Bilateral vocal fold paralysis is a difficult condition to manage, with surgical interventions previously limited to tracheostomy or arytenoidectomy. Re-innervation surgery has been developed and, in recent years, a Laryngeal Pacemaker is now in clinical trials. We speak to two...

Can we prevent chronic rhinosinusitis?

The old adage ‘prevention is better than cure’ is considered by Professor Hopkins in respect to chronic rhinosinusitis, a condition affecting around 10% of the adult population and associated with huge impact on quality of life and economic cost. A...

Laryngeal Manifestations of Systemic Diseases

Laryngeal Manifestations of Systemic Diseases is a unique reference manual which will cater to a wide potential audience. It would represent a good text for laryngologists coming across patients with known comorbidities or as new diagnoses of underlying pathologies, but...

Pediatric Ear Diseases: Diagnostic Imaging Atlas and Case Reports

This book has been painstakingly compiled to produce a detailed atlas of high resolution CT images of the paediatric temporal bone. The five chapters over 160 pages and 242 high quality figures are very well structured and thoughtfully laid out....

Surgery of vestibular schwannomas with peritumoral oedema

This is an interesting retrospective study evaluating peritumoral oedema on magnetic resonance images and correlating it with the intra-operative tumour characteristics and outcome. The study results found that vestibular schwannomas with peritumoral oedema were associated with greater incidence of hypervascularity...

Role of the insula and orbitofrontal cortex in tinnitus related distress

It is estimated that 5% of the population suffer from chronic tinnitus with 17% of those suffering emotional distress. The authors attempted to study the neural correlates of tinnitus-related distress using functional magnetic resonance imaging (fMRI) during an Emotional Stroop...

Implantable devices and large magnets – do they mix well?

Although all brands are MRI safe at 1.5 T, the active middle ear implant system Vibrant Soundbridge (VSB), is special since it houses two magnets. These include a magnetic floating mass transducer (FMT) and an audioprocessor fixing receiver magnet which...

BAHA stability measurement in children

This useful paper reports the experience of using resonance frequency analysis for single stage bone-conduction implants in a paediatric population. A smartpegTM is attached to the abutment and vibrated by a close quarters magnetic field. The amount of vibration is...

Algorithm for malignant otitis externa

Timely detection and effective management of this potentially fatal condition cannot be overemphasised. This study presents 16 cases over 12 months in a tertiary referral centre. Most patients had diabetes and others were immunocompromised due to radiotherapy, immunosuppressive medication or...