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The structure and function of DNA

DNA structure and replication Genetic information within multicellular organisms, including man, is stored in molecules of deoxyribonucleic acid (DNA), which reside within the chromosomes of each cell nucleus. A DNA molecule consists of two very long chains, or strands, of...

From surgeon to scholar: the remarkable life of Philip Stell

Professor Philip Stell was an extraordinary man: following an astonishingly illustrious career in ENT, he excelled as a medieval historian. With the Philip Stell Prize due to be awarded in May, his friend Pat Bradley looks back at his remarkable...

Plasticity with cochlear implants: individual factors in the outcomes

Andrej Kral gives us an overview of neuronal plasticity in congenital hearing loss, and discusses why it is core to our clinical interventions in hearing loss and rehabilitation. The brain is born immature and undergoes extensive shaping during early development....

Internet-based cognitive behavioural therapy for adults with tinnitus

Tinnitus remains one of the most prevalent and distressing audiological symptoms. Although specialist tinnitus services are in high demand, geographical and service constraints result in limited access to these services. Internet-based cognitive behavioural therapy (ICBT) has been developed to provide...

Harnessing head and neck cancer genomics for personalised medicine

Luc Morris updates us on the future of cancer diagnosis and treatment, which lies in “personalised oncology”, where specific molecular alterations of each tumour will be identified, and matched with actionable alterations in existing therapies, ushering in the era of...

Endotypes in chronic rhinosinusitis: clinical relevance

Identifying endotypes enables personalised therapies that target specific pathophysiological processes, potentially resulting in better treatment outcomes for patients. The contemporary model of chronic rhinosinusitis (CRS) pathogenesis revolving around endotype, in combination with an expanding toolbox of diagnostics and therapeutics, enables...

Jameel Muzaffar, Anne Schilder and James O’Hara

In a follow-up to the interview with Anne Schilder back in 2016*, Jameel Muzaffar speaks to Anne and to James O’Hara about the current research landscape in ENT in the UK. *Banerjee A. In conversation with Professor Anne Schilder. ENT...

Dizziness: confusion, issues and considerations

Douglas L Beck gives his unique take on the difficulties involved in diagnosing dizzy patients and the importance of well-founded research acting as the basis for any diagnosis and treatment decisions. Dizziness. Uh-oh. We really have a very limited understanding...

Clinical utility and practical interpretation of the video head impulse test

The head impulse test (HIT) is an essential bedside test to detect peripheral vestibular deficits. The video head impulse test (vHIT) is a new tool quantifying the HIT. In this article Maria Heuberger and colleagues point out the clinical utility...

What’s new in auditory processing?

Auditory processing disorder (APD) has had a controversial history, stemming mainly from lack of scientific rigor and accepted clinical definition. That situation is now changing. Driven by the huge number of people with unaddressed listening difficulties, basic discoveries in neuroscience,...