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Endoscopic middle ear surgery for cholesteatoma treatment
A critical question when any new technique is proposed is ‘does it work?’ In this article Daniele Marchioni and Davide Soloperto discuss the success rates of endoscopic ear surgery for cholesteatoma. Introduction Surgical management of cholesteatoma is still a controversial...
A therapeutic algorithm for tracheoesophageal periprosthetic leakage
Tracheoesophageal voice prosthesis leakage can be intravalvular (more common) or periprosthetic (focus of this study). The authors studied the causes of periprosthetic leakage among 115 patients attending for voice prosthesis management (1374 clinic attendances) treated between December 2014 to December...An update on laryngeal reinnervation
Laryngeal paralysis remains very difficult to treat, but reinnervation offers many attractions. Laryngeal paralysis presents a unique and varied problem that requires a patient centred approach and a range of treatment options depending on laryngeal and patient factors. There is...Precision and personalised genomic and epigenomic medicine in audiology/hearing loss
A detailed look at the pathogenesis of acquired hearing loss due to exposure to ototoxicity during pregnancy or shortly after birth. Insights from genomic medicine have shown that, along with environmental factors causing epigenetic alterations, hearing loss may be caused...Mind the gap – developing a sustainable pipeline for hearing therapeutics
In this article, the authors describe three key challenges faced in developing hearing therapeutics. Collaboration between companies, sectors and disciplines will be key to finding solutions. The unmet need for therapies for hearing loss grows apace, with prevalence rising across...
Scalp reconstruction a new algorithm
Reconstruction of the scalp after acquired defects remains a common challenge for the reconstructive surgeon, especially in light of a history of radiation to the area. Wound healing by secondary intention or with a wound vacuum assisted closure are viable...
