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Investigation of the role of KPNA2 biomarker in oral SCC invasiveness

1 October 2018 | | ENTA - Head & Neck | interleukin-1β (IL-1β), invasiveness, karyopherin alpha 2 (KPNA2), matrix metalloproteinase (MMP), oral cavity squamous cell carcinoma (SCC), survival
This edition of Head and Neck has a strong focus on studies using immunohistochemistry (IHC) to elucidate potential roles of various cell-signalling molecules in both HNSCC and thyroid cancer. The ‘cellular-protein heavy’ title of this article may be off-putting to...

The lateral neck cystic mass – diagnostic dilemma. Can HPV status help?

1 January 2019 | | Branchial cleft cyst, Cystic lymph node metastasis, Cystic neck mass, Fine needle aspiration cytology, HPV DNA
Solitary cystic masses in the lateral neck can present a significant diagnostic dilemma as they can be metastases from tumours of the oro or nasopharynx. This retrospective paper detailed all patients presenting to a university hospital in Germany, from September...
Head & Neck journal cover image

Active smoking predicts poor outcome in HPV positive oropharyngeal squamous cell carcinoma

30 April 2020 | | ENTA - Head & Neck | human papillomavirus, oropharyngeal cancer, overall survival, pack-years, smoking status
Tobacco smoking is a well-known risk factor in human papilloma virus (HPV)-negative head and neck squamous cell cancer. Its effects include increased risk of treatment failure, distant metastases and reduced overall survival. HPV has been increasingly implicated as a causative...

Old age is hard to swallow

4 May 2023 | | ENTA - ENT, ENTA - Laryngology / Swallowing / Voice
This article takes us through the diagnosis and management of swallowing problems common in older age. As our global population continues to grow and live longer, dysphagia will continue to be a global problem which needs to be recognised, understood...

First International Congress on the Management of Head & Neck Paragangliomas

20 September 2023 -23 September 2023 | ENTA - ENT, ENTA - Head & Neck
Renato Mariani-Costantini, MD, Center for Advanced Studies and Technology, Gabriele d’Annunzio University, 66100, Chieti, Italy, and Karel Pacak, MD, PhD, DSc, FACE, Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of...

Thyroid cancer – the last decade

1 July 2017 | | ENTA - ENT, ENTA - Head & Neck, ENTA - Thyroid / Parathyroid Surgery
Professor Ashok Shaha describes the evolution in the treatment of thyroid cancer that he has witnessed over the last decade and the invaluable progress made by himself and others, from their contributions to staging systems and guidelines. Nuances and paradigm...

Surgical challenges in advanced or recurrent thyroid malignancy

1 July 2017 | | ENTA - ENT, ENTA - Head & Neck, ENTA - Thyroid / Parathyroid Surgery
The management of thyroid malignancy and extent of surgery is controversial, especially considering the limitations of preoperative diagnosis. Neil Tolley provides guidance and reminds us of our responsibility not to over-treat. In the UK, 16% of thyroidectomies are performed for...

When dinosaurs ruled the earth

2 September 2022 | | ENTA - ENT
Optimism is abundant in medical research, but frequently ends up being tempered with reality. In his inimitable style, Chris Potter looks back over his career – starting with his medical school memories of Bentley-driving ENT consultants, and moving forward through...

Nuclear heads – and necks

1 May 2014 | | ENTA - ENT, ENTA - Head & Neck
Imaging of the extra-cranial head and neck is challenging due to the anatomic complexity of the region. CT, MRI and ultrasonography (US) are amongst the most frequently utilised radiological modalities in head and neck imaging but do not always provide...

Systemic agents in thyroid cancer

1 July 2017 | | ENTA - ENT, ENTA - Head & Neck, ENTA - Thyroid / Parathyroid Surgery
For those patients who have disseminated or unresectable thyroid cancer, Dr Arabella Hunt and Dr Kate Newbold review systemic treatments, their differences, toxicities and outcomes. Thyroid cancer is the most common endocrine malignancy. It is subdivided into differentiated (papillary, follicular...

In conversation with Professor Eugene Myers: My life in ENT

1 July 2014 | | ENTA - ENT, ENTA - Head & Neck
In a series of interviews, former Chairman of the Editorial Board for ENT & audiology news, Professor Patrick J Bradley, speaks with eminent otolaryngologists who have retired (or are about to retire) from practice. Our first is with Professor Gene...

Cancer genetics and signalling pathways in ENT – a review and discussion of how this can be applied to rare tumours

1 November 2014 | | ENTA - ENT, ENTA - Genetics
Introduction Cancer cases continue to increase worldwide, and­­ head and neck cancer is a major global health issue, with an estimated global burden of over 630,000 new cases and over 350,000 deaths per year [1]. The term ‘head and neck...