You searched for "genetic"

957 results found

Surviving oropharyngeal squamous cell carcinoma – does subsite matter?

Human papilloma virus (HPV) status is a known prognostic factor in oropharyngeal squamous cell carcinoma (OPSCC). The eighth edition of American Joint Cancer Committee (AJCC) has modified the TNM staging to reflect this. However, subsite as an independent prognostic factor...

The Royal Society of Medicine: Otology Section (2018-19)

The forthcoming RSM Otology section programme promises to deliver a series of forward-looking and thought-provoking meetings. The year begins in November with personal insights from incoming Section President, Richard Irving, about the influences on his practice and his career in...

Focus on ENT trainees with additional qualifications

In this Trainee Matters, we focus on ENT trainees with additional qualifications. Eight accomplished trainees tell Emma Stapleton how their achievements have benefitted them both professionally and personally. Their professional achievements have included a National Training Number in ENT, presentations,...

Cancer genetics and signalling pathways in ENT – a review and discussion of how this can be applied to rare tumours

Introduction Cancer cases continue to increase worldwide, and­­ head and neck cancer is a major global health issue, with an estimated global burden of over 630,000 new cases and over 350,000 deaths per year [1]. The term ‘head and neck...

CIGICON 2019: The 17th Annual Conference of the Cochlear Implant Group of India

Reported by: Dr Swathi Vadlamani, Postdoctoral Fellow in Otology at Apollo Hospitals, Bengaluru, India. The Cochlear implant Group of India (CIGI) is a growing conglomeration of professionals consisting of audiologists, otorhinolaryngologists and habilitationists who are devoted to the cause and...

Database WG2. The Tinnitus Patient Database in the TINNET COST Action BM1306

Berthold Langguth describes an innovative project that is creating the world’s largest multi-national patient database containing standardised information on tinnitus and medical history, otological examination and psycho-acoustic measures of tinnitus. A challenge for tinnitus treatment and tinnitus research is the...

The future of head and neck cancer surgery

Neil Sharma paints an exciting picture of the future of head and neck surgery with nanobots and robot augmented humans – science fiction or reality? Time will tell. ‘May you live in interesting times’ reads the old Chinese curse. The...

Hearing loss in the young and self-esteem

How can those involved in the care of children with hearing loss identify those at risk of low self-esteem? This study provides some guidance. Overall differences from hearing peers in terms of communication skills, physical appearance and social maturity place...

Ballenger’s Otorhinolaryngology: Head and Neck Surgery, 18th Edition

One hundred and eight years after its first edition, the two-volume eighteenth edition of Ballenger’s Otorhinolaryngology is published in1300 pages set out in six sections, 114 chapters ably edited by Ashley Wackym and James Snow. Volume one very comprehensively covers...

Clinicopathological features of follicular variant of papillary thyroid carcinoma

The follicular variant (FV) of papillary thyroid carcinoma (PTC) is characterised by the presence of nuclear features of PTC together with a follicular growth pattern. It is currently reported to make up 11.8% to 53.3% of all PTC cases. It...

Recurrent ENT infections in children – is it a sign of primary immunodeficiency disease?

ENT clinicians often come across children with recurrent ear, sinus and pulmonary infections. These recurrent infections, albeit common in childhood, can represent an early sign of primary immunodeficiency diseases (PIDD). PIDD is an underdiagnosed group of genetic disorders involving absent...

The polyp shrinker

Inflammatory markers, including T2 cells beta common (βc) cytokines IL-3, IL5 and granulocyte-macrophage colony-stimulating factor (GM-CSF), are known to play an important role in chronic rhinosinusitis with nasal polyps (CRSwNP). CSL311, a monoclonal antibody (mAb), was developed to target human...