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The integration of targeted therapy and surgery in advanced thyroid cancer clinical trials

One of the headline speakers, Mark Zafereo, will be talking at IFOS about thyroid cancer. We hear from his team about some of the areas they will be discussing. Locally advanced thyroid cancer generally refers to patients who have significant...

The changing landscape of thyroid and parathyroid surgery

How has clinical practice in the management of thyroid and parathyroid disease has evolved in recent years? I perform very few head & neck operations where the patient tells me just one week following surgery that they ‘feel much better’....

Biologic therapies for chronic rhinosinusitis with nasal polyps: a new paradigm

Surgery for nasal polyposis has evolved significantly in the last 30 years, and now the medical management may be on the cusp of a revolution. Biologics using monoclonal antibodies to target specific immune pathways have introduced a paradigm shift in...

My experience of addiction

In this incredibly honest and thought-provoking article, we hear from an anonymous doctor who has struggled with addiction. The nature of addiction is a subject of interest to a broad range of scientific disciplines, from medicine to psychology, psychotherapy and...

Burnout: is this just a pandemic phenomenon?

The phrase ‘burnout’ is often heard, but what is it, and what are the early warning signs? Importantly, how can it be prevented or managed? Over the last few years, health professional wellbeing, mental health, and burnout have come to...

Malignant lesions and reconstruction of the pinna

External ear reconstruction can be challenging. Baskaran Ranganathan and Amr Abdelhamid describe how careful assessment, planning and surgery following the subunit principles and reconstructive ladder will ultimately lead to good aesthetic outcomes with restored form and function. The external ear,...

Endolymphatic sac surgery: controversial procedure for the treatment of Ménière’s disease

Landmark Paper: Thomsen J, Bretlau P, Tos M, Johnsen NJ. Ménière’s disease: endolymphatic sac decompression compared with sham (placebo) decompression. Ann N Y Acad Sci 1981;374:820-30. Of all of the chapters in the Landmark Papers book, the chapter that discussed...

Detecting cancer margins during robotic head and neck cancer surgery using ambient mass spectrometry

We have known about altered metabolism in cancer cells since Otto Warburg described it 97 years ago. But can we take advantage of this knowledge in curing cancer? Jim Higginson explains the value of smoke generated during cancer surgery. The...

Setting up a robotic surgical practice: view from India

Transoral robotic surgery has an established role in head and neck cancer surgery. But how easy is it to set up a service in a resource-constrained environment? Gouri Pantvaidya and Ameya Pai give us a view from the Indian subcontinent....

Long-term outcomes of children and young people with cochlear implants

Introduction Profound childhood hearing loss has a huge impact on early communication skills, the acquisition of spoken language, and hence on educational attainments and employment prospects. Over the centuries, educators of the deaf attempted to overcome the challenge by using...

Hearing loss and Alport syndrome

Alport syndrome (AS) includes a group of hereditary diseases caused by mutations in the COL4A3, COL4A4 or COL4A5 genes. These genes are responsible for the biosynthesis of α3, α4 and α5 collagen IV chains, which are located in the glomerular...