You searched for "disease"

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Brussels, a multicultural city with varied ENT practice

Brussels has a proud history in the world of ENT. Jérome Lechien, who is on the Communications Committee for the CEORL-HNS 2019 Congress, and Daniele de Siati, a member of the international Scientific Committee, give us a history lesson and...

Hearing loss and Alport syndrome

Alport syndrome (AS) includes a group of hereditary diseases caused by mutations in the COL4A3, COL4A4 or COL4A5 genes. These genes are responsible for the biosynthesis of α3, α4 and α5 collagen IV chains, which are located in the glomerular...

Atlas of Ear Diseases

In this self-published atlas, the author has approached the external ear and middle ear pathologies on the basis of classification of diseases, emphasising the added benefits of using of an oto-endoscope in identifying the external and middle ear pathologies. The...

The common frontal sinusotomy (Lothrop) and chronic rhinosinusitis

As our understanding of the pathophysiology of CRS evolves, so do our treatment strategies. It is accepted that in many cases, the main role of surgery is to allow better penetration of topical therapies to the sinus cavities. What, then,...

Timing of surgery in chronic rhinosinusitis: does it matter?

While many patients with chronic rhinosinusitis respond to medical treatment, some do not. The next step for these patients is surgery, but how soon should this be offered? Sooner rather than later seems to be the answer, as Claire Hopkins...

Otology training in low- and middle-income countries: a view from within

It is recognised that hearing loss and ear disease are far more common in less affluent parts of the world, and that those countries are often least able to provide treatment; so how can we prioritise care for these patients?...

Functional Endoscopic Sinus Surgery (FESS) - Part 1

In the first of a two-part series, Martyn Barnes and colleagues discuss indications for functional endoscopic sinus surgery (FESS), the surgical objectives and techniques, patient expectations and the risks of surgery. In part two, the authors will discuss how to...

The curse of Sports Illustrated

“Not a supernatural curse, but a basic statistical concept of blinding simplicity.” What is ‘regression to the mean’? I am reliably informed that our former North American colonies publish a periodical known as Sports Illustrated (note, incidentally, the characteristically incorrect...

Neck dissection in adenoid cystic carcinoma is a risk worth taking?

This paper from Stanford University presents impressive figures to guide the debate on the extent of surgical management in adenoid cystic disease. Adenoid cystic carcinomas present a particular problem in that they can recur even after 20 years. They have...

MRI evaluation to assess the role of frusemide in reducing endolymphatic hydrops

Endolymphatic hydrops is generally considered to be a marker in Ménière’s disease and frusemide is used with the purpose of reducing it and improving symptoms. With the use of MRI, the authors have used the phenomenon of non-enhancing endolymphatic structures...

How should I excise sinonasal tumours, open or endoscopic? En bloc or piecemeal?

Sinonasal tumours often present late because initial symptoms mimic benign disease. They tend to produce more unilateral nasal symptoms, and patients with advance disease often describe paraesthesia and other cranial neuropathies. They only account for approximately 3% of upper aerodigestive...

Can we predict how much benefit patients will get from ESS with a novel monoclonal antibody

Mepolizumab (Nucala) is a humanised IgG1 monoclonal antibody that acts as an IL-5 antagonist. It has been shown to be highly effective in treating severe asthma. It is hypothesised that it will be effective for patients with recalcitrant CRSwNP. This...