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The process of medical innovation

You’ve got an amazing idea for a new device. It is going to change how your speciality of surgery is practised. It will lead to better operative results and lower risks to patients – that’s amazing, can I see it?...

Aboriginal and Torres Strait Islander ear health in the 2020s

The world is in the midst of a pandemic, and global health is severely threatened by this novel coronavirus which has caused over three million infections of COVID-19 and claimed more than 228,000 lives to date*. Societies and health systems...

The art of hearing: a conversation between silence and colour

The image on the ENT & Audiology News September/October 2025 cover is not merely an artwork – it is a conversation. A conversation in colour. A dialogue between silence and sound, between science and emotion. It is part of a...

COVID-19: UCT-Africa Virtual ENT transcends academic silos

The COVID-19 pandemic has been a global catastrophe with far-reaching consequences felt across many fronts around the world. One such aspect is the training of the future generation of ENT surgeons. With routine elective activity curtailed, academic conferences cancelled, and...

Can we predict how much benefit patients will get from ESS with a novel monoclonal antibody

Mepolizumab (Nucala) is a humanised IgG1 monoclonal antibody that acts as an IL-5 antagonist. It has been shown to be highly effective in treating severe asthma. It is hypothesised that it will be effective for patients with recalcitrant CRSwNP. This...

Long-term results for dupilumab are very promising!

Eosinophilic chronic rhinosinusitis (eCRS) is complicated by frequent early and aggressive recurrence of polyps after both medical and surgical treatment regimes. Dupilumab is an anti-IL-4/IL-3 receptor monoclonal antibody and has been previously studied in the SINUS-52 study, with an observation...

A useful adjuvant treatment for SNAC or IP

5-Fluorouracil (5FU) is a topical preparation used in the treatment of various dermatological, ocular and gynaecologic malignant and pre-malignant conditions, and this literature review looks at the efficacy of 5FU in treating inverted papilloma and sinonasal tumours. The authors cite...

Armageddon and surgical outcomes

In the excitement of the festive season I am sure many of you will have omitted to commemorate the 60th anniversary of a highly significant world event. According to a small apocalyptic cult led by a Chicago housewife named Dorothy...

Superior semicircular canal dehiscence: transmastoid obliteration

Sometimes patients with dizziness turn out to have slightly more unusual causes of their problem. Thomas Milner and Georgios Kontorinis describe their technique for managing patients who have a diagnosis of superior canal dehiscence as an identified cause of their...

Patients with severe uncontrolled CRSwNP respond to biologics in the real world

Clinical trials have demonstrated that biologics are effective in treating patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This multicentre (15 tertiary care centres in France) observational prospective cohort study aims to examine the effectiveness of biologics in treating CRSwNP...

The common frontal sinusotomy (Lothrop) and chronic rhinosinusitis

As our understanding of the pathophysiology of CRS evolves, so do our treatment strategies. It is accepted that in many cases, the main role of surgery is to allow better penetration of topical therapies to the sinus cavities. What, then,...

Building sound: from Stonehenge to a Symphony Hall

Modern architecture can use scientific techniques to shape room acoustics and create great sounding places. Professor Trevor Cox discusses our ancestors’ understanding of the importance of building techniques to enhance acoustics from Stonehenge to a Symphony Hall. Going to an...