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Discovery in the genetics of complex disease: Otitis media
Otitis media (OM), a common disease of childhood, is considered to be a complex trait with multiple genetic and environmental factors expected to contribute to a child’s risk of developing recurrent acute OM (rAOM; ≥3 episodes in 6 months or...
Poking the bear: learning to drain quinsy on a mannequin head
Simulation in medicine has gained significant traction in both undergraduate and postgraduate training over the last couple of decades or so – the benefits to all involved are clear. The airline industry models for human factors and crew resource management...
Patient-reported outcome measures: what do the people say?
Patient-reported outcome measures (PROMs) assess and quantify health outcomes from the patient’s perspective. Defining these questionnaires as outcomes indicates that they are psychometrically sensitive to change. This article describes three PROMS: namely the Patient Reported Outcome Measurement Information System (PROMIS),...The evolution in management of microtia and atresia
The management of microtia and atresia has evolved significantly. Ossama Abdelhamid and Amr Abdelhamid explain how a multidisciplinary approach has become standard, with the aim of delivering individualised assessment and intervention that should target functional, structural, cosmetic and psychological aspects...
Diagnostic features of acute invasive fungal sinusitis
Acute invasive fungal sinusitis (AIFS) is a rare but frequently lethal condition, commonly associated with a high morbidity among those that survive. It has gained recent media attention on account of its increased incidence following infection with (and treatment for)...
The Human Ear Canal
If ever a book aptly lived up to its name, it would be ‘The Human Ear Canal’ by Dr Ballachandra. Not once straying from its path, this second edition aims to take the reader on a somewhat tangential tour of...A binaural detection task that reveals deficits in listeners having ‘slight’ or ‘hidden’ hearing loss
The association of degraded binaural processing in adults with clinically defined ‘slight’ or ‘hidden’ high frequency hearing loss is of great interest to clinicians if it can be measured. Leslie R Bernstein and Constantine Trahiotis share their findings in measurements...A surgeon’s perspective on the challenges facing cochlear implantation in children
Cochlear implantation in children offers a different set of challenges and goals to adult practice. In this article, Iain Bruce, Professor of Paediatric Otolaryngology in Manchester, UK, explains some of the current clinical and research challenges in paediatric cochlear implantation,...
An algorithm to distinguish between distant metastases and metachronous lung primary in patients with HPV-related oropharyngeal cancer
Distinguishing between distant metastases of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) and metachronous primary lung squamous cell carcinoma (SCC) is important as it has implications for treatment, prognosis counselling, and registry data. Although p16 immunohistochemistry (p16 IHC) is widely accepted...Endotypes in chronic rhinosinusitis: clinical relevance
Identifying endotypes enables personalised therapies that target specific pathophysiological processes, potentially resulting in better treatment outcomes for patients. The contemporary model of chronic rhinosinusitis (CRS) pathogenesis revolving around endotype, in combination with an expanding toolbox of diagnostics and therapeutics, enables...Noise monitoring on a smartphone
“The smartphone has more computing power than was used to put the first man on the moon.” Robert Eikelboom discusses the potential of the smartphone as an effective noise monitoring device. Noise exposure and public health Excessive exposure to noise...
